Prof. Jens Pahnke and his group have been conducting research projects in the field of Alzheimer’s disease and other neurodegenerative diseases for many years. They have also been DeePathology STUDIO users almost from the beginning of our journey.
They have previously published an article comparing the STUDIO’s deep learning experience to more traditional digital image analysis methods in analysing tissue from and Alzheimer’s disease mouse model (Bascuñana, Brackhan and Pahnke, 2020). Here, they described that using the STUDIO not only greatly reduced on-hands analysis time from hours to minutes, but also made it possible to detect different object categories (for example dense and diffuse plaques) when analysing immunohistological tissue sections.
In a follow-up publication in the Journal of Neuroscience Methods from this year, the Pahnke Lab provided a comprehensive introduction to using the STUDIO’s Objects Mode (Möhle et al., 2021). The Objects Mode of the DeePathology STUDIO is a versatile tool to detect different kind of objects and cells in whole slide images. In this paper, the Pahnke Lab covered the basic principles of AI model creation in the STUDIO and demonstrated them by creating three different algorithms to detect microglia cells in IBA1-stained FFPE mouse brain sections.
Do you also have a neuroscience use case and would like to use the STUDIO to solve your problem? Contact us to spark a discussion – we’re looking forward to your challenges!
If you’re curious how others use the DeePathology STUDIO, have a look at our other articles and webinars.
